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noun
pain, agony
Synonyms: ache, affliction, anguish, anxiety, bad news, blues, care, concern, cross, dejection, desolation, disappointment, discomfort, disquietude, dolor, embarrassment, grief, headache, heartache, heartbreak, irritation, malaise, misery, mortification, ordeal, pang, perplexity, sadness, shame, sorrow, stew, suffering, throe, torment, torture, trial, tribulation, trouble, twinge, unconsolability, unhappiness, vexation, visitation, woe, worriment, worry, wretchedness
Antonyms: comfort, happiness, health, pleasure
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noun
hardship, adversity
Synonyms: bad luck, bummer, calamity, can of worms, catastrophe, crunch, destitution, difficulty, disaster, downer, drag, exigency, hard knocks, hard time, holy mess, hot water, indigence, jam, misfortune, need, pickle, pinch, poverty, privation, rigor, rotten luck, scrape, straits, throe, ticklish spot, tough break, tough luck, trial, trouble, unholy mess, vicissitude, want
Antonyms: advantage, benefit, miracle
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verb
worry, upset
Synonyms: afflict, aggrieve, agonize, ail, be on one’s case, bother, break, bug, burn up, depress, desolate, discombobulate, disquiet, disturb, do a number on, dog, eat, get, get to, give a hard time, grieve, harass, harry, hound, hurt, injure, irk, irritate, make it tough for, miff, nag, needle, nit-pick, oppress, pain, peeve, perplex, pester, pick on, plague, push, push buttons, rack, sadden, strain, strap, stress, tick off, torment, torture, trouble, try, vex, weigh, wound
Antonyms: assist, calm, comfort, help, soothe